McGhee Tyson ANGB is the home of the 134th Air Refueling Wing (134 ARW) of the Tennessee Air National Guard, an Air Mobility Command (AMC) gained unit which functions as the host wing for the installation. Other tenants of the base include the 119th Command and Control Squadron the I.G. Brown Air National Guard Training and Education Center, Air National Guard Band of the South, and the 1st Squadron, 230th Armored Cavalry Regiment's Army Aviation Support Facility of the Tennessee Army National Guard, operating several OH-58 Kiowa Warrior helicopters.

Federal: Support Rapid Global Mobility and Sustainment by providing world class personnel, vital Air Refueling and Airlift capabilities for contingency response and sustained combat operations

State: Provide personnel and equipment to protect life and property during emergency response operations as directed by the Governor of Tennessee and the Adjutant General